Shift work and cardiovascular risk

@HealthMed It is well-known that shift workers have increased risk factors for serious heart disease, for example as reported in Knuttson's 1986 Lancet paper on papermill workers. They are more likely to smoke and tend to have higher blood pressure, cholesterol and weight and be more likely to have diabetes than  workers whose work pattern is confined to the daytime. They are also more likely to have insomnia, itself an independent risk factor for cardiovascular disease. Clinical pharmacologist Daniel Hackem from Ontario and his colleagues from Norway, Sweden and the USA had now raised further public and health professional interest in this disease link in a paper published in the British Medical Journal.

They looked at 34 previous studies of over 2 million shiftworkers. Together, there were over 17,000 heart events, over 6000 heart attacks and almost 2000 strokes. They concluded that stroke risk was around 5% higher and coronary event risk 24% higher in the shift-workers. Surprisingly, despite their large dataset, the researchers found no associated increase in mortality.

They take care to point out, as with any other observational study, that this is not necessarily a cause and effect relationship. People who take on shift work may be different in some unconnected way that puts up risk of vascular disease. Lower socio-economic status is an obvious important confounder. The work itself may be more stressful, at the same time as their being fewer other staff members in support 'out of hours'. Shift workers may also take more caffeine to try to stay alert during often long shifts.

Nonetheless there are several key messages reinforced by this report.

Shift-workers are more likely to have an excess of a wide range of cardiovascular risk factors. They  should therefore be encouraged to seek regular medical advice and their employers to raise awareness of these health risks and to support their staff in seeking regular medical advice. Shift-workers should also be supported in ensuring a healthy lifestyle despite the constraints on exercise and diet of unsocial hours of work.

Clinical pharmacologists and other health professionals should make sure to take a good occupational health history, including identifying whether a patient does shift work. They should make sure particular  care is taken to identify and reduce severity of cardiovascular risk factors in shift workers, supported by effective regular advice on healthy lifestyle. And where drug treament is indicated, prescribing treatment targets should be adjusted to take account of the increased cardiovascular risk to be prevented.

Employers should also make sure that patterns of shift work follow international guidance regarding avoiding abrupt shift changes, maximum shift duration and ensuring sufficient staff are working 'out of hours' to ensure that work is done both safely for employers' outcomes as well as their workers' health.

Microcirculation and the 2012 UK-US international Conference

@HealthMed The MicroCirc2012 conference at Keble College Oxford, 4-6 July, was co-organized by the British Microcirculation Society and the US Microcirculatory Society. 

Why study the microcirculation? The microvessels - small arteries, capillaries and small venules - play a vital role in providing nutrition to and removing waste products from vital organs. Microvessels are also critical for healthy maintenance of blood pressure. 

D Singer and PhD student H Saedon at MicroCirc2012

And in a wide range of diseases, a spectrum of inflammatory factors, acting on and/or derived from the microcirculation, contribute to disease causation and severity, and provide both biomarkers and targets for prevention and treatment of serious diseases from cardiovascular syndromes to diabetes, inflammatory disease and cancer, and from early abnormalities in the fetal circulation to diseases of ageing. 

A series of delegates posts are now appearing from the MicroCirc2012 conference, from a wide range of specialists, from molecular biologists to imagers, and from 1st year PhD students to senior academics. 

See more about the microcirculation and the 2012 Conference in reflections of principal organizer Professor Chris Garland, posts from delegates and in video interviews with Professor Giovanni Mann from King's College London, and Professor Steven Segal from Columbus, Missouri, USA.